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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF3I All Species: 44.85
Human Site: S238 Identified Species: 89.7
UniProt: Q13347 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13347 NP_003748.1 325 36502 S238 P V N S A A L S P N Y D H V V
Chimpanzee Pan troglodytes XP_001161562 325 36425 S238 P V N S A A L S P N Y D H V V
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_535328 325 36439 S238 P V N S A A L S P N Y D H V V
Cat Felis silvestris
Mouse Mus musculus Q9QZD9 325 36442 S238 P V N S A A L S P N Y D H V V
Rat Rattus norvegicus B0BNA7 325 36442 S238 P V N S A A L S P N Y D H V V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001157867 325 36471 S238 P V N S A A L S P I F D H V V
Frog Xenopus laevis Q66J51 325 36477 S238 P V N S A A V S P I Y D H V V
Zebra Danio Brachydanio rerio Q7ZV55 325 36268 S238 P V N S A A I S P I M D H V V
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02195 326 36141 S240 P V N S A A I S P I M D H V V
Honey Bee Apis mellifera XP_392780 326 36609 S239 P V N S A T I S P I F D H V V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40217 347 38737 T246 P L N T A V I T P L K E F I I
Red Bread Mold Neurospora crassa Q7RXH4 346 38778 T241 P L N S A T I T R K K D F V I
Conservation
Percent
Protein Identity: 100 77.5 N.A. 99.3 N.A. 99.3 99.3 N.A. N.A. 94.1 89.8 83.6 N.A. 60.7 59.8 N.A. N.A.
Protein Similarity: 100 80.3 N.A. 99.6 N.A. 100 100 N.A. N.A. 97.5 97.2 93.5 N.A. 77.3 78.2 N.A. N.A.
P-Site Identity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 86.6 86.6 80 N.A. 80 73.3 N.A. N.A.
P-Site Similarity: 100 100 N.A. 100 N.A. 100 100 N.A. N.A. 93.3 93.3 86.6 N.A. 86.6 86.6 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 43.8 49.4
Protein Similarity: N.A. N.A. N.A. N.A. 63.6 66.4
P-Site Identity: N.A. N.A. N.A. N.A. 26.6 40
P-Site Similarity: N.A. N.A. N.A. N.A. 73.3 66.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 100 75 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 92 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 17 0 17 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 84 0 0 % H
% Ile: 0 0 0 0 0 0 42 0 0 42 0 0 0 9 17 % I
% Lys: 0 0 0 0 0 0 0 0 0 9 17 0 0 0 0 % K
% Leu: 0 17 0 0 0 0 50 0 0 9 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 17 0 0 0 0 % M
% Asn: 0 0 100 0 0 0 0 0 0 42 0 0 0 0 0 % N
% Pro: 100 0 0 0 0 0 0 0 92 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % R
% Ser: 0 0 0 92 0 0 0 84 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 9 0 17 0 17 0 0 0 0 0 0 0 % T
% Val: 0 84 0 0 0 9 9 0 0 0 0 0 0 92 84 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 50 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _